Ontology highlight
ABSTRACT:
SUBMITTER: Kugou K
PROVIDER: S-EPMC2704158 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Kugou Kazuto K Fukuda Tomoyuki T Yamada Shintaro S Ito Masaru M Sasanuma Hiroyuki H Mori Saori S Katou Yuki Y Itoh Takehiko T Matsumoto Kouji K Shibata Takehiko T Shirahige Katsuhiko K Ohta Kunihiro K
Molecular biology of the cell 20090513 13
Spo11-mediated DNA double-strand breaks (DSBs) that initiate meiotic recombination are temporally and spatially controlled. The meiotic cohesin Rec8 has been implicated in regulating DSB formation, but little is known about the features of their interplay. To elucidate this point, we investigated the genome-wide localization of Spo11 in budding yeast during early meiosis by chromatin immunoprecipitation using high-density tiling arrays. We found that Spo11 is dynamically localized to meiotic chr ...[more]