From broken to old: DNA damage, IGF1 endocrine suppression and aging.
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ABSTRACT:
SUBMITTER: Monnat RJ
PROVIDER: S-EPMC2704237 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
From broken to old: DNA damage, IGF1 endocrine suppression and aging.
DNA repair 20070503 9
Two recent reports provide new information on how DNA damage may generate progeroid changes at the cell and organismal level by suppressing growth hormone (GH)/insulin-like growth factor 1 (IGF1) endocrine signaling. This endocrine signaling pathway is of particular interest as it is a key regulator of metabolism and longevity in many organisms. ...[more]
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