Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont.
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ABSTRACT:
SUBMITTER: McCutcheon JP
PROVIDER: S-EPMC2704378 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont.
McCutcheon John P JP McDonald Bradon R BR Moran Nancy A NA
PLoS genetics 20090717 7
The genetic code relates nucleotide sequence to amino acid sequence and is shared across all organisms, with the rare exceptions of lineages in which one or a few codons have acquired novel assignments. Recoding of UGA from stop to tryptophan has evolved independently in certain reduced bacterial genomes, including those of the mycoplasmas and some mitochondria. Small genomes typically exhibit low guanine plus cytosine (GC) content, and this bias in base composition has been proposed to drive UG ...[more]
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