Ontology highlight
ABSTRACT:
SUBMITTER: Scherr N
PROVIDER: S-EPMC2704726 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Scherr Nicole N Müller Philipp P Perisa Damir D Combaluzier Benoît B Jenö Paul P Pieters Jean J
Journal of bacteriology 20090515 14
Pathogenic mycobacteria survive within macrophages through the inhibition of phagosome-lysosome fusion. A crucial factor for avoiding lysosomal degradation is the mycobacterial serine/threonine protein kinase G (PknG). PknG is released into the macrophage cytosol upon mycobacterial infection, suggesting that PknG might exert its activity by interfering with host signaling cascades, but the mode of action of PknG remains unknown. Here, we show that PknG undergoes autophosphorylation on threonine ...[more]