Ontology highlight
ABSTRACT:
SUBMITTER: Laguette N
PROVIDER: S-EPMC2704780 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Laguette Nadine N Brégnard Christelle C Bouchet Jérôme J Benmerah Alexandre A Benichou Serge S Basmaciogullari Stéphane S
Journal of virology 20090513 14
Human immunodeficiency virus type 1 (HIV-1) Nef interferes with the endocytic machinery to modulate the cell surface expression of CD4. However, the basal trafficking of CD4 is governed by different rules in the target cells of HIV-1: whereas CD4 is rapidly internalized from the cell surface in myeloid cells, CD4 is stabilized at the plasma membrane through its interaction with the p56(lck) kinase in lymphoid cells. In this study, we showed that Nef was able to downregulate CD4 in both lymphoid ...[more]