Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki H
PROVIDER: S-EPMC2704976 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Arteriosclerosis, thrombosis, and vascular biology 20081218 2
<h4>Background</h4>Although, endothelial nitric oxide (NO) synthase (eNOS) is believed to antagonize vascular remodeling induced by the angiotensin II (AngII) type-1 receptor, the exact signaling mechanism remains unclear.<h4>Methods and results</h4>By expressing eNOS to vascular smooth muscle cells (VSMCs) via adenovirus, we investigated a signal transduction mechanism of the eNOS gene transfer in preventing vascular remodeling induced by AngII. We found marked inhibition of AngII-induced Rho/R ...[more]