Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC27051 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Li X X Commane M M Nie H H Hua X X Chatterjee-Kishore M M Wald D D Haag M M Stark G R GR
Proceedings of the National Academy of Sciences of the United States of America 20000901 19
Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifu ...[more]