Ontology highlight
ABSTRACT:
SUBMITTER: Volker J
PROVIDER: S-EPMC2705181 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Völker Jens J Plum G Eric GE Klump Horst H HH Breslauer Kenneth J KJ
Journal of the American Chemical Society 20090701 26
Enhanced levels of DNA triplet expansion are observed when base excision repair (BER) of oxidative DNA base damage (e.g., 8-oxo-dG) occurs at or near CAG repeat sequences. This observation suggests an interplay between processing mechanisms required for DNA repair and expansion pathways that yield genotypes associated with many neurological/developmental disorders. It has been proposed that DNA expansion involves the transient formation within the triplet repeat domains of non-native slipped DNA ...[more]