Ontology highlight
ABSTRACT:
SUBMITTER: Cinnamon Y
PROVIDER: S-EPMC2705188 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Cinnamon Yuval Y Feine Oren O Hochegger Helfrid H Bershadsky Alexander A Brandeis Michael M
PloS one 20090714 7
<h4>Background</h4>Cellular contractility, essential for cell movement and proliferation, is regulated by microtubules, RhoA and actomyosin. The RhoA dependent kinase ROCK ensures the phosphorylation of the regulatory Myosin II Light Chain (MLC) Ser19, thereby activating actomyosin contractions. Microtubules are upstream inhibitors of contractility and their depolymerization or depletion cause cells to contract by activating RhoA. How microtubule dynamics regulates RhoA remains, a major missing ...[more]