Ontology highlight
ABSTRACT:
SUBMITTER: Narayan K
PROVIDER: S-EPMC2705189 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
PloS one 20090709 7
The superantigen SEA causes non-specific hyperactivation of T and B cells at low concentrations. Studies of mutants or soluble proteins suggest SEA is bivalent for its ligand, MHC class II. However, the interaction between these molecules on intact cells is unknown. On primary mouse B cells expressing the MHC class II allele HLA-DR1, measurements of Förster Resonance Energy Transfer between HLA-DR1 molecules on SEA-treated cells indicated specific clustering, not observed in untreated or monoval ...[more]