Ontology highlight
ABSTRACT:
SUBMITTER: Ueda R
PROVIDER: S-EPMC2705554 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Ueda Ryo R Kohanbash Gary G Sasaki Kotaro K Fujita Mitsugu M Zhu Xinmei X Kastenhuber Edward R ER McDonald Heather A HA Potter Douglas M DM Hamilton Ronald L RL Lotze Michael T MT Khan Saleem A SA Sobol Robert W RW Okada Hideho H
Proceedings of the National Academy of Sciences of the United States of America 20090611 26
The RNase III endonuclease Dicer plays a key role in generation of microRNAs (miRs). We hypothesized that Dicer regulates cancer cell susceptibility to immune surveillance through miR processing. Indeed, Dicer disruption up-regulated intercellular cell adhesion molecule (ICAM)-1 and enhanced the susceptibility of tumor cells to antigen-specific lysis by cytotoxic T-lymphocytes (CTLs), while expression of other immunoregulatory proteins examined was not affected. Blockade of ICAM-1 inhibited the ...[more]