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Molecular recognition and self-assembly special feature: Assembly and organization processes in DNA-directed colloidal crystallization.

ABSTRACT: We present an analysis of the key steps involved in the DNA-directed assembly of nanoparticles into crystallites and polycrystalline aggregates. Additionally, the rate of crystal growth as a function of increased DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA linker strands (1- versus 2-component systems) has been studied. The data show that the crystals grow via a 3-step process: an initial "random binding" phase resulting in disordered DNA-AuNP aggregates, followed by localized reorganization and subsequent growth of crystalline domain size, where the resulting crystals are well-ordered at all subsequent stages of growth.

SUBMITTER: Macfarlane RJ

PROVIDER: S-EPMC2705589 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Molecular recognition and self-assembly special feature: Assembly and organization processes in DNA-directed colloidal crystallization.

Macfarlane Robert J RJ Lee Byeongdu B Hill Haley D HD Senesi Andrew J AJ Seifert Soenke S Mirkin Chad A CA

Proceedings of the National Academy of Sciences of the United States of America 20090619 26

We present an analysis of the key steps involved in the DNA-directed assembly of nanoparticles into crystallites and polycrystalline aggregates. Additionally, the rate of crystal growth as a function of increased DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA linker strands (1- versus 2-component systems) has been studied. The data show that the crystals grow via a 3-step process: an initial "random binding" phase resulting in disordered DNA-AuN ...[more]

PMID: 19549828

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