Ontology highlight
ABSTRACT:
SUBMITTER: Conlan AR
PROVIDER: S-EPMC2705628 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Conlan Andrea R AR Paddock Mark L ML Axelrod Herbert L HL Cohen Aina E AE Abresch Edward C EC Wiley Sandra S Roy Melinda M Nechushtai Rachel R Jennings Patricia A PA
Acta crystallographica. Section F, Structural biology and crystallization communications 20090627 Pt 7
A primary role for mitochondrial dysfunction is indicated in the pathogenesis of insulin resistance. A widely used drug for the treatment of type 2 diabetes is pioglitazone, a member of the thiazolidinedione class of molecules. MitoNEET, a 2Fe-2S outer mitochondrial membrane protein, binds pioglitazone [Colca et al. (2004), Am. J. Physiol. Endocrinol. Metab. 286, E252-E260]. The soluble domain of the human mitoNEET protein has been expressed C-terminal to the superfolder green fluorescent protei ...[more]