Ontology highlight
ABSTRACT:
SUBMITTER: Cong Y
PROVIDER: S-EPMC2705691 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Cong Yao Y Zhang Qinfen Q Woolford David D Schweikardt Thorsten T Khant Htet H Dougherty Matthew M Ludtke Steven J SJ Chiu Wah W Decker Heinz H
Structure (London, England : 1993) 20090501 5
Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respectively. SDS can convert inactive PO and the oxygen carrier hemocyanin (Hc) into enzymatically active PO. Here we present single-particle cryo-EM maps at subnanometer resolution and pseudoatomic models of the 24-oligomeric Hc from scorpion Pandinus imperator in resting and SDS-activat ...[more]