Unknown

Dataset Information

0

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.


ABSTRACT: T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th17 cell lineage and Th17 cell-mediated autoimmunity. IL-1 receptor1 expression in T cells, which was induced by IL-6, was necessary for the induction of experimental autoimmune encephalomyelitis and for early Th17 cell differentiation in vivo. Moreover, IL-1 signaling in T cells was required in dendritic cell-mediated Th17 cell differentiation from naive or regulatory precursors and IL-1 synergized with IL-6 and IL-23 to regulate Th17 cell differentiation and maintain cytokine expression in effector Th17 cells. Importantly, IL-1 regulated the expression of the transcription factors IRF4 and RORgammat during Th17 cell differentiation; overexpression of these two factors resulted in IL-1-independent Th17 cell polarization. Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology.

SUBMITTER: Chung Y 

PROVIDER: S-EPMC2705871 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications


T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th17 cell lineage and Th17 cell-mediated autoimmunity. IL-1 receptor1 expression in T cells, which was induced by IL-6, was necessary for the induction of experimental autoimmune encephalomyelitis and for early Th17 cell differentiation in vivo. Moreover, IL-1 signaling in T cells was required in dendritic ce  ...[more]

Similar Datasets

| S-EPMC3423893 | biostudies-other
| S-EPMC10849914 | biostudies-literature
| S-EPMC2710918 | biostudies-literature
| S-EPMC6361668 | biostudies-literature
2019-01-28 | PXD008973 | Pride
| S-EPMC7411462 | biostudies-literature
| S-EPMC9122603 | biostudies-literature
| S-EPMC3131467 | biostudies-literature
| S-EPMC7068643 | biostudies-literature
| S-EPMC5628272 | biostudies-literature