Ontology highlight
ABSTRACT:
SUBMITTER: Chung Y
PROVIDER: S-EPMC2705871 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Chung Yeonseok Y Chang Seon Hee SH Martinez Gustavo J GJ Yang Xuexian O XO Nurieva Roza R Kang Hong Soon HS Ma Li L Watowich Stephanie S SS Jetten Anton M AM Tian Qiang Q Dong Chen C
Immunity 20090409 4
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th17 cell lineage and Th17 cell-mediated autoimmunity. IL-1 receptor1 expression in T cells, which was induced by IL-6, was necessary for the induction of experimental autoimmune encephalomyelitis and for early Th17 cell differentiation in vivo. Moreover, IL-1 signaling in T cells was required in dendritic ce ...[more]