Ontology highlight
ABSTRACT:
SUBMITTER: Dankort D
PROVIDER: S-EPMC2705918 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Dankort David D Curley David P DP Cartlidge Robert A RA Nelson Betsy B Karnezis Anthony N AN Damsky William E WE You Mingjian J MJ DePinho Ronald A RA McMahon Martin M Bosenberg Marcus M
Nature genetics 20090312 5
Mutational activation of BRAF is the earliest and most common genetic alteration in human melanoma. To build a model of human melanoma, we generated mice with conditional melanocyte-specific expression of BRaf(V600E). Upon induction of BRaf(V600E) expression, mice developed benign melanocytic hyperplasias that failed to progress to melanoma over 15-20 months. By contrast, expression of BRaf(V600E) combined with Pten tumor suppressor gene silencing elicited development of melanoma with 100% penet ...[more]