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Gene-expression signatures of Atlantic salmon's plastic life cycle.


ABSTRACT: How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators.

SUBMITTER: Aubin-Horth N 

PROVIDER: S-EPMC2706306 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Gene-expression signatures of Atlantic salmon's plastic life cycle.

Aubin-Horth Nadia N   Letcher Benjamin H BH   Hofmann Hans A HA  

General and comparative endocrinology 20090503 3


How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at si  ...[more]

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