Ontology highlight
ABSTRACT:
SUBMITTER: West S
PROVIDER: S-EPMC2706331 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
West Steven S Proudfoot Nicholas J NJ
Molecular cell 20090201 3
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage, which occurs either at the pA site or in transcripts from terminator elements. Although this process has been extensively studied, it is generally considered inconsequential to the level of gene expression. However, our results demonstrate that te ...[more]