Ontology highlight
ABSTRACT:
SUBMITTER: Crosier MD
PROVIDER: S-EPMC2706526 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Crosier Michael D MD Booth Sarah L SL Peter Inga I Dawson-Hughes Bess B Price Paul A PA O'Donnell Christopher J CJ Hoffmann Udo U Williamson Matthew K MK Ordovas Jose M JM
Journal of nutritional science and vitaminology 20090201 1
Matrix Gla protein (MGP) is a key regulator of vascular calcification. Genetic variation at the MGP locus could modulate the development of coronary artery calcification (CAC). Our aim was to examine the cross-sectional association between MGP single nucleotide polymorphisms (SNPs) [rs1800802 (T-138C), rs1800801 (G-7A), and rs4236 (Ala102Thr)] and CAC. CAC was measured by multidetector computed tomography (MDCT), in older men and women of European descent, (n=386; 60 to 80 y of age). Serum MGP w ...[more]