Ontology highlight
ABSTRACT:
SUBMITTER: Culley FJ
PROVIDER: S-EPMC2707003 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Culley Fiona J FJ Johnson Matthew M Evans J Henry JH Kumar Sunil S Crilly Rupert R Casasbuenas Juan J Schnyder Tim T Mehrabi Maryam M Deonarain Mahendra P MP Ushakov Dmitry S DS Braud Veronique V Roth Günter G Brock Roland R Köhler Karsten K Davis Daniel M DM
PLoS biology 20090728 7
Natural killer (NK) cells discern the health of other cells by recognising the balance of activating and inhibitory ligands expressed by each target cell. However, how the integration of activating and inhibitory signals relates to formation of the NK cell immune synapse remains a central question in our understanding of NK cell recognition. Here we report that ligation of LFA-1 on NK cells induced asymmetrical cell spreading and migration. In contrast, ligation of the activating receptor NKG2D ...[more]