Ontology highlight
ABSTRACT:
SUBMITTER: Zhu P
PROVIDER: S-EPMC2709280 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Zhu Ping P Zhou Wenlai W Wang Jianxun J Puc Janusz J Ohgi Kenneth A KA Erdjument-Bromage Hediye H Tempst Paul P Glass Christopher K CK Rosenfeld Michael G MG
Molecular cell 20070801 4
Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 wi ...[more]