The RNA-induced silencing complex: a versatile gene-silencing machine.
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ABSTRACT:
SUBMITTER: Pratt AJ
PROVIDER: S-EPMC2709356 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
The RNA-induced silencing complex: a versatile gene-silencing machine.
Pratt Ashley J AJ MacRae Ian J IJ
The Journal of biological chemistry 20090401 27
RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually any nucleic acid sequence for silencing. The ability of RISC to locate target RNAs has been co-opted by evolution many times to generate a broad spectrum of gene-silencing pathways. Here, we review the ...[more]
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