Ontology highlight
ABSTRACT:
SUBMITTER: Dai H
PROVIDER: S-EPMC2709361 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Dai Haiming H Meng X Wei XW Lee Sun-Hee SH Schneider Paula A PA Kaufmann Scott H SH
The Journal of biological chemistry 20090407 27
The release of cytochrome c from mitochondria, which leads to activation of the intrinsic apoptotic pathway, is regulated by interactions of Bax and Bak with antiapoptotic Bcl-2 family members. The factors that regulate these interactions are, at the present time, incompletely understood. Recent studies showing preferences in binding between synthetic Bcl-2 homology domain 3 and antiapoptotic Bcl-2 family members in vitro have suggested that the antiapoptotic proteins Mcl-1 and Bcl-x(L), but not ...[more]