Ontology highlight
ABSTRACT:
SUBMITTER: Ito T
PROVIDER: S-EPMC2709453 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Ito Tomoki T Hanabuchi Shino S Wang Yi-Hong YH Park Woong Ryeon WR Arima Kazuhiko K Bover Laura L Qin F Xiao-Feng FX Gilliet Michel M Liu Yong-Jun YJ
Immunity 20080529 6
Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and control autoimmunity through a cell-contact-dependent mechanism. We found two subsets of FOXP3+ natural Treg cells defined by the expression of the costimulatory molecule ICOS in the human thymus and periphery. Whereas the ICOS+FOXP3+ Treg cells used interleukin-10 to suppress dendritic cell function and transforming growth factor (TGF)-beta t ...[more]