Ontology highlight
ABSTRACT:
SUBMITTER: Yosef N
PROVIDER: S-EPMC2709590 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Yosef Nir N Kupiec Martin M Ruppin Eytan E Sharan Roded R
Nucleic acids research 20090522 12
The recent availability of protein-protein interaction networks for several species makes it possible to study protein complexes in an evolutionary context. In this article, we present a novel network-based framework for reconstructing the evolutionary history of protein complexes. Our analysis is based on generalizing evolutionary measures for single proteins to the level of whole subnetworks, comprehensively considering a broad set of computationally derived complexes and accounting for both s ...[more]