Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC2709691 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Zhou Wenhua W Kalivas Peter W PW
Biological psychiatry 20070824 3
<h4>Background</h4>Previous studies show that the acute administration of N-acetylcysteine (NAC) inhibits the desire for cocaine in addicts and cocaine-seeking in animals.<h4>Methods</h4>Rats were trained to self-administer heroin, and the reinstatement model of drug seeking was used to determine whether chronic NAC treatment inhibited heroin-seeking.<h4>Results</h4>Daily NAC administration inhibited cue- and heroin-induced seeking. Moreover, repeated NAC administration during extinction trainin ...[more]