Unknown

Dataset Information

0

Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4.

ABSTRACT: GABRA2 and GABRG1, which encode the alpha-2 and gamma-1 subunits, respectively, of the GABA(A) receptor, are located in a cluster on chromosome 4p. The GABRA2 locus has been found to be associated with alcohol dependence in several studies, but no functional variant that can account for this association has been identified. To understand the reported associations, we sought to understand the linkage disequilibrium (LD) patterns and haplotype structures of these genes. With close intergenic distance, approximately 90 kb, it was anticipated that some markers might show intergenic LD. Variation in 13-SNP haplotype block structure was observed in five different populations: European American, African American, Chinese (Han and Thai), Thai, and Hmong. In the Hmong, a 280-kb region of considerably higher LD spans the intergenic region, whereas in other populations, there were two or more LD blocks that cross this region. These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations.

SUBMITTER: Ittiwut C 

PROVIDER: S-EPMC2709929 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4.

Ittiwut Chupong C   Listman Jennifer J   Mutirangura Apiwat A   Malison Robert R   Covault Jonathan J   Kranzler Henry R HR   Sughondhabirom Atapol A   Thavichachart Nuntika N   Gelernter Joel J  

Genomics 20071105 1

GABRA2 and GABRG1, which encode the alpha-2 and gamma-1 subunits, respectively, of the GABA(A) receptor, are located in a cluster on chromosome 4p. The GABRA2 locus has been found to be associated with alcohol dependence in several studies, but no functional variant that can account for this association has been identified. To understand the reported associations, we sought to understand the linkage disequilibrium (LD) patterns and haplotype structures of these genes. With close intergenic dista  ...[more]

Similar Datasets

Unknown A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5.
| S-EPMC310801 | biostudies-literature
Unknown Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.
| S-EPMC2743531 | biostudies-literature
Unknown Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions.
| S-EPMC3922197 | biostudies-literature
Unknown Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.
| S-EPMC4067321 | biostudies-literature
Unknown Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus.
| S-EPMC2850168 | biostudies-literature
Unknown GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.
| S-EPMC2656604 | biostudies-literature
Unknown GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.
| S-EPMC3250564 | biostudies-literature
Unknown Extensive intragenic recombination and patterns of linkage disequilibrium at the CSN3 locus in European rabbit.
| S-EPMC2682830 | biostudies-other
Unknown Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.
| S-EPMC1180604 | biostudies-literature
Unknown Chromosome-wide linkage disequilibrium as a consequence of meiotic drive.
| S-EPMC1785283 | biostudies-literature