Stress, genes and the biology of suicidal behavior.
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ABSTRACT:
SUBMITTER: Currier D
PROVIDER: S-EPMC2710608 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Publications
Stress, genes and the biology of suicidal behavior.
Currier Dianne D Mann J John JJ
The Psychiatric clinics of North America 20080601 2
Suicidal behavior is partly heritable. Studies seeking the responsible candidate genes have examined genes involved in neurotransmitter systems shown to have altered function in suicide and attempted suicide. These neurotransmitter systems include the serotonergic, noradrenergic, and dopaminergic systems and the hypothalamic-pituitary-adrenal axis. With some exceptions, most notably the serotonin transporter gene promoter polymorphism (HTTLPR), replication of candidate gene association studies f ...[more]
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