Ontology highlight
ABSTRACT:
SUBMITTER: Gao D
PROVIDER: S-EPMC2710831 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Gao Daming D Inuzuka Hiroyuki H Korenjak Michael M Tseng Alan A Wu Tao T Wan Lixin L Kirschner Marc M Dyson Nicholas N Wei Wenyi W
Molecular biology of the cell 20090528 14
APC/Cdh1 is a major cell cycle regulator and its function has been implicated in DNA damage repair; however, its exact role remains unclear. Using affinity purification coupled with mass spectrometry, we identified Claspin as a novel Cdh1-interacting protein and further demonstrated that Claspin is a novel Cdh1 ubiquitin substrate. As a result, inactivation of Cdh1 leads to activation of the Claspin/Chk1 pathway. Previously, we demonstrated that Rb interacts with Cdh1 to influence its ability to ...[more]