MicroRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells.
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ABSTRACT:
SUBMITTER: Weitzel RP
PROVIDER: S-EPMC2710921 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells.
Weitzel R Patrick RP Lesniewski Mathew L ML Haviernik Peter P Kadereit Suzanne S Leahy Patrick P Greco Nicholas J NJ Laughlin Mary J MJ
Blood 20090313 26
The reduced expression of nuclear factor of activated T cells-1 (NFAT1) protein in umbilical cord blood (UCB)-derived CD4+ T cells and the corresponding reduction in inflammatory cytokine secretion after stimulation in part underlies their phenotypic differences from adult blood (AB) CD4+ T cells. This muted response may contribute to the lower incidence and severity of high-grade acute graft-versus-host disease (aGVHD) exhibited by UCB grafts. Here we provide evidence that a specific microRNA, ...[more]
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