Ontology highlight
ABSTRACT:
SUBMITTER: Swann JB
PROVIDER: S-EPMC2710930 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Swann Jeremy B JB Uldrich Adam P AP van Dommelen Serani S Sharkey Janelle J Murray William K WK Godfrey Dale I DI Smyth Mark J MJ
Blood 20090220 25
CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking eit ...[more]