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Type I natural killer T cells suppress tumors caused by p53 loss in mice.

ABSTRACT: CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking either type I NKT cells (TCR Jalpha18(-/-)) or all CD1d-restricted T cells (CD1d(-/-)). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development.

SUBMITTER: Swann JB 

PROVIDER: S-EPMC2710930 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Type I natural killer T cells suppress tumors caused by p53 loss in mice.

Swann Jeremy B JB   Uldrich Adam P AP   van Dommelen Serani S   Sharkey Janelle J   Murray William K WK   Godfrey Dale I DI   Smyth Mark J MJ  

Blood 20090220 25

CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking eit  ...[more]