Purifying selection and birth-and-death evolution in the ubiquitin gene family.
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ABSTRACT:
SUBMITTER: Nei M
PROVIDER: S-EPMC27115 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Publications
Purifying selection and birth-and-death evolution in the ubiquitin gene family.
Nei M M Rogozin I B IB Piontkivska H H
Proceedings of the National Academy of Sciences of the United States of America 20000901 20
Ubiquitin is a highly conserved protein that is encoded by a multigene family. It is generally believed that this gene family is subject to concerted evolution, which homogenizes the member genes of the family. However, protein homogeneity can be attained also by strong purifying selection. We therefore studied the proportion (p(S)) of synonymous nucleotide differences between members of the ubiquitin gene family from 28 species of fungi, plants, and animals. The results have shown that p(S) is ...[more]
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