Cellular entry and nuclear targeting by a highly anionic molecular umbrella.
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ABSTRACT:
SUBMITTER: Mehiri M
PROVIDER: S-EPMC2711778 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Cellular entry and nuclear targeting by a highly anionic molecular umbrella.
Mehiri Mohamed M Jing Bingwen B Ringhoff Danielle D Janout Vaclav V Cassimeris Lynne L Regen Steven L SL
Bioconjugate chemistry 20080806 8
A fluorescently labeled, persulfated molecular umbrella ( 1) has been synthesized from cholic acid, lysine, spermine, and Coumarin 343 and found capable of entering live HeLa cells. The distributions of 1 throughout the cytoplasm and the nucleus were diffuse and punctate, respectively. This finding, together with its ability to cross liposomal membranes by passive diffusion, suggests that passive diffusion plays a significant role in the ability of 1 to enter cells. The fact that 1 is concentrat ...[more]
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