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The role of human orbitofrontal cortex in value comparison for incommensurable objects.

ABSTRACT: The human orbitofrontal cortex is strongly implicated in appetitive valuation. Whether its role extends to support comparative valuation necessary to explain probabilistic choice patterns for incommensurable goods is unknown. Using a binary choice paradigm, we derived the subjective values of different bundles of goods, under conditions of both gain and loss. We demonstrate that orbitofrontal activation reflects the difference in subjective value between available options, an effect evident across valuation for both gains and losses. In contrast, activation in dorsal striatum and supplementary motor areas reflects subjects' choice probabilities. These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making.

SUBMITTER: FitzGerald TH

PROVIDER: S-EPMC2712081 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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The role of human orbitofrontal cortex in value comparison for incommensurable objects.

FitzGerald Thomas H B TH Seymour Ben B Dolan Raymond J RJ

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701 26

The human orbitofrontal cortex is strongly implicated in appetitive valuation. Whether its role extends to support comparative valuation necessary to explain probabilistic choice patterns for incommensurable goods is unknown. Using a binary choice paradigm, we derived the subjective values of different bundles of goods, under conditions of both gain and loss. We demonstrate that orbitofrontal activation reflects the difference in subjective value between available options, an effect evident acro ...[more]

PMID: 19571129

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