Ontology highlight
ABSTRACT:
SUBMITTER: Ito K
PROVIDER: S-EPMC2712082 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Nature 20080511 7198
The existence of a small population of 'cancer-initiating cells' responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia-initiating cells, particularly those that are in a quiescent state, are thought to be resistant to chemotherapy and targeted therapies, resulting in disease relapse. Chronic myeloid leukaemia is a paradigmatic haematopoietic stem cell disease in which the leukaemia-initiating-cell pool is ...[more]