Ontology highlight
ABSTRACT:
SUBMITTER: Schulman BA
PROVIDER: S-EPMC2712597 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Schulman Brenda A BA Harper J Wade JW
Nature reviews. Molecular cell biology 20090408 5
Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through multienzyme cascades is a central mechanism to modulate protein functions. This process is initiated by a family of mechanistically and structurally related E1 (or activating) enzymes. These activate UBLs through carboxy-terminal adenylation and thiol transfer, and coordinate the use of UBLs in specific downstream pathways by charging cognate E2 (or conjugating) enzymes, which then interact with the downs ...[more]