Ontology highlight
ABSTRACT:
SUBMITTER: Hegedus C
PROVIDER: S-EPMC2713039 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
FEBS letters 20080424 12
The goal of the current study, conducted in freshly isolated thymocytes was (1) to investigate the possibility that the activation of poly(ADP-ribose) polymerase-1 (PARP-1) in an intact cell can be regulated by protein kinase C (PKC) mediated phosphorylation and (2) to examine the consequence of this regulatory mechanism in the context of cell death induced by the genotoxic agent. In cells stimulated by the PKC activating phorbol esters, DNA breakage was unaffected, PARP-1 was phosphorylated, 1- ...[more]