Ontology highlight
ABSTRACT:
SUBMITTER: Peng YR
PROVIDER: S-EPMC2713111 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Peng Yi-Rong YR He Shan S Marie Helene H Zeng Si-Yu SY Ma Jun J Tan Zhu-Jun ZJ Lee Soo Yeun SY Malenka Robert C RC Yu Xiang X
Neuron 20090101 1
Neural circuit development requires concurrent morphological and functional changes. Here, we identify coordinated and inversely correlated changes in dendritic morphology and mEPSC amplitude following increased neural activity. We show that overexpression of beta-catenin, a molecule that increases total dendritic length, mimics the effects of increased neuronal activity by scaling down mEPSC amplitudes, while postsynaptic expression of a protein that sequesters beta-catenin reverses the effects ...[more]