Ontology highlight
ABSTRACT:
SUBMITTER: Grandy D
PROVIDER: S-EPMC2713547 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Grandy David D Shan Jufang J Zhang Xinxin X Rao Sujata S Akunuru Shailaja S Li Hongyan H Zhang Yanhui Y Alpatov Ivan I Zhang Xin A XA Lang Richard A RA Shi De-Li DL Zheng Jie J JJ
The Journal of biological chemistry 20090421 24
Dishevelled (Dvl) is an essential protein in the Wnt signaling pathways; it uses its PDZ domain to transduce the Wnt signals from the membrane receptor Frizzled to downstream components. Here, we report identifying a drug-like small molecule compound through structure-based ligand screening and NMR spectroscopy and show the compound to interact at low micromolar affinity with the PDZ domain of Dvl. In a Xenopus testing system, the compound could permeate the cell membrane and block the Wnt signa ...[more]