Ontology highlight
ABSTRACT:
SUBMITTER: Vellanki SH
PROVIDER: S-EPMC2713593 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Vellanki Sri Hari Krishna SH Grabrucker Andreas A Liebau Stefan S Proepper Christian C Eramo Adriana A Braun Veit V Boeckers Tobias T Debatin Klaus-Michael KM Fulda Simone S
Neoplasia (New York, N.Y.) 20090801 8
Because evasion of apoptosis can cause radioresistance of glioblastoma, there is a need to design rational strategies that counter apoptosis resistance. In the present study, we investigated the potential of targeting the antiapoptotic protein XIAP for the radiosensitization of glioblastoma. Here, we report that small-molecule XIAP inhibitors significantly enhance gamma-irradiation-induced loss of viability and apoptosis and cooperate with gamma-irradiation to suppress clonogenic survival of gli ...[more]