Unknown

Dataset Information

0

Cost-effectiveness of lifestyle modification in diabetic patients.


ABSTRACT: OBJECTIVE To explore the potential long-term health and economic consequences of lifestyle interventions for diabetic patients. RESEARCH DESIGN AND METHODS A literature search was performed to identify interventions for diabetic patients in which lifestyle issues were addressed. We selected recent (2003-2008), randomized controlled trials with a minimum follow-up of 12 months. The long-term outcomes for these interventions, if implemented in the Dutch diabetic population, were simulated with a computer-based model. Costs and effects were discounted at, respectively, 4 and 1.5% annually. A lifelong time horizon was applied. Probabilistic sensitivity analyses were performed, taking account of variability in intervention costs and (long-term) treatment effects. RESULTS Seven trials with 147-5,145 participants met our predefined criteria. All interventions improved cardiovascular risk factors at > or =1 year follow-up and were projected to reduce cardiovascular morbidity over lifetime. The interventions resulted in an average gain of 0.01-0.14 quality-adjusted life-years (QALYs) per participant. Health benefits were generally achieved at reasonable costs (< or =euro50,000/QALY). A self-management education program (X-PERT) and physical activity counseling achieved the best results with > or =0.10 QALYs gained and > or =99% probability to be very cost-effective (< or =euro20,000/QALY). CONCLUSIONS Implementation of lifestyle interventions would probably yield important health benefits at reasonable costs. However, essential evidence for long-term maintenance of health benefits was limited. Future research should be focused on long-term effectiveness and multiple treatment strategies should be compared to determine incremental costs and benefits of one over the other.

SUBMITTER: Jacobs-van der Bruggen MA 

PROVIDER: S-EPMC2713648 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


OBJECTIVE To explore the potential long-term health and economic consequences of lifestyle interventions for diabetic patients. RESEARCH DESIGN AND METHODS A literature search was performed to identify interventions for diabetic patients in which lifestyle issues were addressed. We selected recent (2003-2008), randomized controlled trials with a minimum follow-up of 12 months. The long-term outcomes for these interventions, if implemented in the Dutch diabetic population, were simulated with a c  ...[more]

Similar Datasets

| S-EPMC4020006 | biostudies-literature
| S-EPMC8876590 | biostudies-literature
| S-EPMC5831594 | biostudies-literature
| S-EPMC7489415 | biostudies-literature
| S-EPMC7772323 | biostudies-literature
| S-EPMC8456662 | biostudies-literature
| S-EPMC7502894 | biostudies-literature
| S-EPMC7527375 | biostudies-literature
| S-EPMC3737388 | biostudies-literature
| S-EPMC7156872 | biostudies-literature