Ontology highlight
ABSTRACT:
SUBMITTER: Tan ES
PROVIDER: S-EPMC2713717 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Tan Edwin S ES Groban Eli S ES Jacobson Matthew P MP Scanlan Thomas S TS
Chemistry & biology 20080401 4
The trace amine-associated receptor 1 (TAAR(1)) is a biogenic amine G protein-coupled receptor (GPCR) that is potently activated by 3-iodothyronamine (1, T(1)AM) in vitro. Compound 1 is an endogenous derivative of the thyroid hormone thyroxine which rapidly induces hypothermia, anergia, and bradycardia when administered to mice. To explore the role of TAAR(1) in mediating the effects of 1, we rationally designed and synthesized rat TAAR(1) superagonists and lead antagonists using the rotamer tog ...[more]