Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels.
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ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC2713753 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels.
Singh Amandeep A Wirtz Martin M Parker Nadeene N Hogan Matthew M Strahler John J Michailidis George G Schmidt Sarah S Vidal-Puig Antonio A Diano Sabrina S Andrews Philip P Brand Martin D MD Friedman Jeffrey J
Proceedings of the National Academy of Sciences of the United States of America 20090721 31
Leptin reduces body weight in ob/ob mice by decreasing food intake and increasing energy expenditure; however, the mechanisms by which it does the latter are not known. Here we report that 30% of the weight loss induced by leptin treatment of ob/ob mice is due to changes in energy expenditure. In assessing leptin's effects on specific tissues, we found that hepatic basal metabolic rate was paradoxically decreased 1.7-fold with leptin treatment, which was the result of a 1.6-fold reduction in mit ...[more]
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