Ontology highlight
ABSTRACT:
SUBMITTER: Bogle G
PROVIDER: S-EPMC2713783 | biostudies-literature | 2008 Nov-Dec
REPOSITORIES: biostudies-literature
Immunology and cell biology 20080819 8
Agent-based simulation modelling of T-cell trafficking, activation and proliferation in the lymph node paracortex requires a model for cell motility. Such a model must be able to reproduce the observed random-walk behaviour of T cells, while accommodating large numbers of tightly packed cells, and must be computationally efficient. We report the development of a motility model, based on a three-dimensional lattice geometry, that meets these objectives. Cells make discrete jumps between neighbour ...[more]