Cytokine-secreting follicular T cells shape the antibody repertoire.
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ABSTRACT:
SUBMITTER: Reinhardt RL
PROVIDER: S-EPMC2714053 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
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Cytokine-secreting follicular T cells shape the antibody repertoire.
Reinhardt R Lee RL Liang Hong-Erh HE Locksley Richard M RM
Nature immunology 20090301 4
High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell-dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4-reporter system, we show here that CD4(+) follicular helper T cells constituted essentially all of the cytokine-secreting T cells in lymph nodes and were functionally distinct from T cells secreting the same cytokine in periphe ...[more]
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