Estimating a multivariate familial correlation using joint models for canonical correlations: application to memory score analysis from familial Hispanic Alzheimer's disease study.
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ABSTRACT:
SUBMITTER: Lee HS
PROVIDER: S-EPMC2714197 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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Estimating a multivariate familial correlation using joint models for canonical correlations: application to memory score analysis from familial Hispanic Alzheimer's disease study.
Lee Hye-Seung HS Cho Paik Myunghee M Lee Joseph H JH
Biometrics 20080519 2
<h4>Summary</h4>Analysis of multiple traits can provide additional information beyond analysis of a single trait, allowing better understanding of the underlying genetic mechanism of a common disease. To accommodate multiple traits in familial correlation analysis adjusting for confounders, we develop a regression model for canonical correlation parameters and propose joint modeling along with mean and scale parameters. The proposed method is more powerful than the regression method modeling pai ...[more]
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