Ontology highlight
ABSTRACT:
SUBMITTER: Kalyanaraman C
PROVIDER: S-EPMC2714228 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20081101 11
We have developed a computational approach to aid the assignment of enzymatic function for uncharacterized proteins that uses homology modeling to predict the structure of the binding site and in silico docking to identify potential substrates. We apply this method to proteins in the functionally diverse enolase superfamily that are homologous to the characterized L-Ala-D/L-Glu epimerase from Bacillus subtilis. In particular, a protein from Thermotoga martima was predicted to have different subs ...[more]