Regional and strain-specific gene expression mapping in the adult mouse brain.
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ABSTRACT:
SUBMITTER: Sandberg R
PROVIDER: S-EPMC27144 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Publications
Regional and strain-specific gene expression mapping in the adult mouse brain.
Sandberg R R Yasuda R R Pankratz D G DG Carter T A TA Del Rio J A JA Wodicka L L Mayford M M Lockhart D J DJ Barlow C C
Proceedings of the National Academy of Sciences of the United States of America 20000901 20
To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially expressed between the 129SvEv and C57BL/6 mouse strains at baseline and in response to seizure. In addition, we identified genes that are differentially expressed in specific brain regions. We found that approximately 1% of expressed genes are differentially expressed between strains in at least one ...[more]
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