Ontology highlight
ABSTRACT:
SUBMITTER: Vicente-Manzanares M
PROVIDER: S-EPMC2714416 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Vicente-Manzanares Miguel M Choi Colin Kiwon CK Horwitz Alan Rick AR
Journal of cell science 20090101 Pt 2
The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell, and the dynamic cross-linking of actin filaments promotes adhesion maturation. Breaking the linkage b ...[more]