Rotation of organizer tissue contributes to left-right asymmetry.
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ABSTRACT:
SUBMITTER: Cui C
PROVIDER: S-EPMC2714534 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Rotation of organizer tissue contributes to left-right asymmetry.
Cui Cheng C Little Charles D CD Rongish Brenda J BJ
Anatomical record (Hoboken, N.J. : 2007) 20090401 4
Current hypotheses regarding vertebrate left-right asymmetry patterns are based on the presumption that genetic regulatory networks specify sidedness via extracellular morphogens and/or ciliary activity. We show empirical time-lapse evidence for an asymmetric rotation of epiblastic nodal tissue in avian embryos. This rotation spans the interval when initial symmetric expression of Shh and Fgf8 becomes asymmetrical with respect to the midline. ...[more]
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